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IN VITRO LYMPHOKINE RELEASE BY LYMPHOCYTES FROM MICE INFECTED WITH SALMONELLA
Author(s) -
Attridge SR,
Kotlarski Ieva
Publication year - 1985
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1985.53
Subject(s) - lymphokine , salmonella enteritidis , in vitro , salmonella , microbiology and biotechnology , biology , macrophage , antigen , immunology , bacteria , biochemistry , genetics
Summary Lymphocytes generated in mice by infection with Salmonella enteritidis 11RX release interleukin 2 and macrophage activation factor upon subsequent in vitro culture with bacterial antigens. Lymphokine release requires the co‐culture of non‐adherent sensitized Lyt 1 + 2 ‐ T cells and adherent metabolically active accessory cells; the interaction between these two populations is restricted by the H‐2 I ‐A locus. Following systemic immunization with the 11RX strain, the two lymphokines are produced in parallel by peritoneal cells, whereas spleen cells primarily release macrophage activation factor.