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ALVEOLAR MACROPHAGES: ANTIGEN PRESENTATION ACTIVITY IN VIVO
Author(s) -
Holt PG,
Leivers S
Publication year - 1985
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1985.4
Subject(s) - in vivo , immune system , antigen , in vitro , antigen presentation , microbiology and biotechnology , oxygen tension , immunology , cell , macrophage , antigen presenting cell , chemistry , biology , t cell , oxygen , biochemistry , organic chemistry
Summary Previous studies on the antigen‐presenting of activity of alveolar macrophages (AM) have been restricted to the use of in vitro assay systems, and have generally shown suppression of T cell activation by these macrophages. The present study exploits the rapid adaptability of AM to changes in oxygen tension, which facilitates their transfer to other tissues in a functional state. Employing this rationale, antigen‐pulsed AM were shown to trigger T cell‐dependent immune responses following subcutaneous or intraperitoneal inoculation, while suppressing similar responses in tissue culture.