Premium
VASO‐ACTIVE INTESTINAL PEPTIDE: A NEUROTRANSMITTER WHICH REDUCES HUMAN NK CELL ACTIVITY AND INCREASES Ig SYNTHESIS
Author(s) -
Drew PA,
Shearman DJC
Publication year - 1985
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1985.35
Subject(s) - peripheral blood mononuclear cell , immune system , pokeweed mitogen , neurotransmitter , in vitro , k562 cells , endocrinology , antibody , vasoactive intestinal peptide , biology , medicine , neuropeptide , immunology , chemistry , receptor , biochemistry , central nervous system
Summary The effect of vaso‐active intestinal peptide(VIP)on natural killer (Nk)cell activity and immunoglobulin synthesis in vitro has been Studied. At a concentration of 10 ‐6 M, VIP significantly inhibited the NK cell activity of normal human peripheral blood mononuclear cells (PBMC)on K562 target cells. The concentration of IgG, IgA and IgM in the supernatants of pokeweed mitogen‐stimulated PBMC was increased when VIP was added at the beginning of the culture period. It is possible that VIP may influence immune responses in the intestinal tract, where it is a neurotransmitter and is found in high concentrations.