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THE DEVELOPMENT AND ULTRASTRUCTURE OF PLASMODIUM FALCIPARUM DAMAGED IN VITRO BY HUMAN “CRISIS” SERA AND BY CHLOROQUINE
Author(s) -
Butcher GA,
Maxwell Lesley,
Cowen N,
Clancy RL,
Stace JD
Publication year - 1985
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1985.2
Subject(s) - plasmodium falciparum , chloroquine , cerebral malaria , malaria , in vitro , ultrastructure , virology , immune system , parasite hosting , biology , immunology , biochemistry , anatomy , world wide web , computer science
Summary P. falciparum malaria was cultured in vitro in the presence of sera from patients with cerebral malaria, meningitis and also after choloroquine administration. Intra‐erythrocytic parasite damage was seen by light and electron microscopy. The significance of the results is discussed with relevance to non‐specific immune mechanisms, and the damage induced by these mechanisms compared with that from chloroquine.