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CANNULATION OF THE CISTERNA MAGNA IN SHEEP: A METHOD FOR CHRONIC STUDIES OF CEREBROSPINAL FLUID
Author(s) -
Falconer J,
Owens PC,
Smith R
Publication year - 1985
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1985.17
Subject(s) - cisterna magna , cerebrospinal fluid , cannula , medicine , surgery
Summary A method of cannulating the cisterns magna of sheep is described. Successful cancellations were achieved in 15 of 17 attempts (88%). Mean cannula patency was 13‐9 days (range 7‐20). Using these cannulas, it possible to obtain samples of cerebrospinal fluid (CSF) in large volumes (4‐8 ml) and remove 20‐30 ml of CSF over a 5 h period This technique allows access to the CSF of an animal large enough for the removal of samples of CSF of sufficient size to detect materials present at very low concentrations.