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REVERSIBLE NUTRITIONAL MYOPATHY WITH MYOTONIA IN THE PROTEIN‐DEFICIENT RAT GIVEN METHIONINE
Author(s) -
Cummins AG,
Duncombe VM,
Bolin TD,
Davis AE
Publication year - 1985
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1985.14
Subject(s) - myotonia , myopathy , methionine , weakness , medicine , muscle protein , electromyography , endocrinology , vitamin e deficiency , vitamin e , physical medicine and rehabilitation , biology , biochemistry , anatomy , myotonic dystrophy , skeletal muscle , amino acid , antioxidant
Summary Rats fed a protein‐deficient synthetic diet developed hind limb weakness caused by a myopathy with myotonic features on electromyography. Deficiency of vitamin E and selenium, known causes of nutritional myopathy, were excluded Methionine supplementation of the diet reversed the clinical signs of weakness within 12 h.