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INFECTIONS WITH SALMONELLA TYPHIMURIUM AND NIPPOSTRONGYLUS BRASILIENSIS IN MICE SELECTIVELY REARED FOR HIGH OR LOW IMMUNE RESPONSIVENESS TO NEMATOSPIROIDES DUBIUS
Author(s) -
Sitepu P,
Dobson C,
Brindley PJ
Publication year - 1984
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1984.71
Subject(s) - nippostrongylus brasiliensis , biology , salmonella , microbiology and biotechnology , heterologous , immune system , immunization , immunology , bacteria , gene , biochemistry , genetics
Summary Mice which had been selectively reared over six generations for high (H) and low (L) immune responsiveness to N. dubius (Sitepu and Dobson, 1982) were infected with Salmonella typhimurium and N. brasiliensis to examine the specificity of the selection process for heterologous infections. H mice were marginally more susceptible than L mice to S. typhimurium , whereas H mice were more resistant to infection with N. brasiliensis than L mice. Both H and L mice were protected against N. dubius following immunization with N. brasiliensis larvae.