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THE RELATION BETWEEN TECHNICAL VARIATION AND THE MEAN IN THE MIXED LYMPHOCYTE REACTION IN THE RAT
Author(s) -
Hibberd AD,
Wells JE,
Walker PA,
Lindsay VJ
Publication year - 1984
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1984.67
Subject(s) - mixed lymphocyte reaction , variation (astronomy) , lymphocyte , statistics , parametric statistics , mathematics , transformation (genetics) , immune system , immunology , medicine , chemistry , physics , biochemistry , t cell , astrophysics , gene
Summary Technical variation is a linear function of the incremental mean in the mixed lymphocyte reaction (MLR) and is independent of the immune status of the responders and the gene dose of the stimulators. Logarithmic transformation of the absolute count/control mean makes technical variation independent of the mean. We recommend that this transformation be used before parametric analysis of the data.