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ANTIGEN‐SPECIFIC RESPONSE AMONG T LYMPHOCYTES FOLLOWING INTESTINAL ADMINISTRATION OF ALLOANTIGENS
Author(s) -
Husband AJ,
Dunkley ML,
Cripps AW,
Clancy RL
Publication year - 1984
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1984.65
Subject(s) - antigen , lamina propria , immunology , lymph , t lymphocyte , lymphocyte , mesenteric lymph nodes , lymphatic system , thoracic duct , biology , medicine , spleen , pathology , epithelium
Summary The kinetics of T lymphocyte responses to mucosally presented antigen and the appearance of antigen‐reactive T cells in mucosal and systemic tissues have been investigated by measuring secondary mixed lymphocyte culture reactivity after intestinal administration of alloantigens. The data indicate that T lymphocytes in the intestine are able to respond to mucosally presented alloantigens, and that following immunisation the T cell reactivity occurs first in Peyer's patches then sequentially in mesenteric lymph nodes, thoracic duct lymph, gut lamina propria and distant mucosal sites. The response was mucosally restricted and the ultimate location of antigen‐reactive cells is influenced by site of antigen administration. Evidence is also presented for the existence of systemic non‐reactivity to mucosally presented antigens.