Premium
IMMUNOSUPPRESSION BY HUMAN SKIN CANCERS
Author(s) -
McCabe M,
Nowak M,
Maguire D,
Robertson P
Publication year - 1984
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1984.51
Subject(s) - immunosuppression , medicine , immunology , dermatology
Summary Biopsy samples from normal skin (12 samples) and skin lesions diagnosed as either basal cell (17 cases) or squamous cell carcinoma (5 cases) were frozen, disrupted and extracted with aqueous buffer. The sterilised extract was added to an in vitro system of cultured bovine lymphocytes. The response of the lymphocytes to PHA was measured by tritialed thymidine uptake. Extracts of both basal cell and squamous cell cancers inhibited normal PHA stimulation of lymphocyte mitogenesis. Blastogenesis was reduced by more than 50% by all of the cancer extracts tested. In contrast, similar extracts from normal skin showed less than 40% inhibition.