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EXPERIMENTAL STUDIES ON THE PATHOGENICITY OF VIBRIO MIMICUS STRAINS ISOLATED IN BANGLADESH
Author(s) -
Sanyal Suhas C,
Huq Mohammad I,
Neogy Prodyut KB,
Alam Khorshed,
Kabir Mohammad I,
Rahaman Abu SMH
Publication year - 1984
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1984.48
Subject(s) - toxin , cholera , microbiology and biotechnology , antitoxin , biology , cholera toxin , vibrio cholerae , serotype , vibrio , bacteria , virology , genetics
Summary Vibrio mimicus , a newly described species of the genus Vibrio has been isolated from stools of 14 patients with diarrhoea. Live cells of all the 14 strains tested caused accumulation of fluid in rabbit gut loops and diarrhoea in infant rabbits. Culture filtrates of all the strains caused increased capillary permeability in rabbit skin; however, five of the filtrates resembled cholera toxin in that they gave positive reactions in rabbit loops, chinese hamster ovarian and mouse adrenal cell monolayers and GM 1 ELISA tests and were neutralized by cholera antitoxin. None of the strains produced heat‐stable toxin or possessed invasive capability as determined by Sereny's test. Thus, V. mimicus strains were divided into a group which produced a toxin immunobiologically similar to cholera toxin and the rest producing a heat‐labile toxin unrelated to that of V. cholerae .