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IMPAIRED RENAL CONCENTRATING CAPACITY IN THE RAT AFTER SURGICAL RESECTION OF THE PAPILLA
Author(s) -
Gobe Glenda C,
Axelsen Roy A
Publication year - 1984
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1984.37
Subject(s) - renal papilla , major duodenal papilla , renal function , reabsorption , urology , medicine , kidney , urine flow rate , urinary system , endocrinology , urine osmolality
Summary Renal cortical and medullary function was examined in rats 4 weeks after surgical resection of the distal portion of the renal papilla had been performed. Glomerular filtration rate (GFR), obtained during the determination of free water reabsorption (TcH 2 O) at high rates of urine flow, did not differ significantly among controls (1·62 ± 0·19 m1/min, n = 5), sham operated animals (1·45 ± 0·16, n = 4) and papillectomized animals (1·49 ± 0·21, n = 7). Maximum urinary osmolality (U max ) was 2216 ± 293 mOsm/kg in controls, and was significantly reduced in sham operated (1737 ± 261, P <0·05) and papillectomized animals (889 ± 143, P <0·0001). TcH 2 O was normal in sham operated animals at high rates of osmolar clearance (C oom ), but was significantly impaired after resection of the renal papilla. These results suggest that removal of the terminal collecting ducts and interruption of nephrons with long loops extending into the papilla impair the maximal generation of solute free water.