MACROPHAGES BIND DIRECTLY TO SEMLIKI FOREST VIRUS‐INFECTED CELLS AND MEDIATE ANTIBODY‐DEPENDENT CELL‐MEDIATED CYTOTOXICITY | Zendy

Macfarlan Roderick I | Zendy; White David O | Zendy

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MACROPHAGES BIND DIRECTLY TO SEMLIKI FOREST VIRUS‐INFECTED CELLS AND MEDIATE ANTIBODY‐DEPENDENT CELL‐MEDIATED CYTOTOXICITY

Author(s) -

Macfarlan Roderick I,

White David O

Publication year - 1984

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1984.19

Subject(s) - semliki forest virus , cytotoxicity , antibody dependent cell mediated cytotoxicity , antibody , virology , cell mediated immunity , virus , cell , chemistry , alphavirus , biology , microbiology and biotechnology , immunology , immune system , immunity , in vitro , biochemistry , rna , gene

Summary Macrophages were found to bind directly to Semliki Forest virus (SFV)‐infected, but not uninfected, P815 cells. In the presence of anti‐H‐2 d or anti‐BALB/c antibody, macrophages lysed SFV‐infected, but not uninfected, P815 cells. It is proposed that macrophage‐mediated antibody‐dependent cell‐mediated cytotoxicity (ADCC) proceeds via two functionally distinguishable initial steps: (1) adhesion of effector to target cell, which may be mediated through antibody or through viral protein, as in the case of SFV‐infected target cells suboptimally sensitized with antibody; (2) antibody‐dependent initiation of cytolysis.

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