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EFFECT OF TUMOUR‐ASSOCIATED MACROPHAGES ON THE GROWTH OF TUMOURS IN RATS
Author(s) -
Inoue Y,
Nelson DS
Publication year - 1984
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1984.17
Subject(s) - macrophage , carrageenan , fibrosarcoma , adenocarcinoma , lymph node , pathology , in vitro , cancer research , chemistry , biology , medicine , cancer , biochemistry
Summary Tumours that had grown in syngeneic rats were depleted of macrophages in vitro . A comparison was made with non‐depleted tumours of their growth in the feet and spread to the popliteal lymph nodes in untreated, irradiated (500 rads) or carrageenan‐treated rats. A non‐metastasizing methylcholanthrene‐induced fibrosarcoma (D8) grew better in the feet of all three groups after macrophage depletion but metastasized more extensively only in irradiated rats; irradiation increased the growth of non‐depleted D8 in the feet. D8M, a metastatic variant of D8, grew less extensively in the feet of normal rats after macrophage depletion. Its metastatic spread was increased by macrophage depletion in carrageenan‐treated rats only. Non‐depleted D8M grew less well in the feet of irradiated or carrageenan‐treated rats than in normal rats. A metastasizing spontaneous adenocarcinoma (ST‐2) grew less well in normal rats after macrophage depletion. The non‐depleted tumour grew less well in irradiated rats but macrophage depletion had no further effect. Metastasis of ST‐2 to the popliteal node of normal rats was abolished by macrophage depletion. The nature of the host macrophage‐tumour relationship seems to differ from tumour to tumour.