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INTERACTIONS OF PROTEIN CALORIE MALNUTRITION, MALARIA INFECTION AND IMMUNE RESPONSES
Author(s) -
Bhatia A,
Aggarwal A,
Sehgal S,
Chakravarti RN,
Vinayak VK
Publication year - 1983
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1983.56
Subject(s) - immune system , calorie , plasmodium berghei , biology , malnutrition , immunology , protein calorie malnutrition , malaria , physiology , protein–energy malnutrition , medicine , endocrinology
Summary The course of parashaemia and certain immune responses in prolein or calorie‐deficient albino rats infected with Piasmodium berghei (NICD) were studied. Wide variations observed in the course of parasitaemia in protein‐deficient animals were (a) prolonged prepatent period, short patent period with low para‐silaemia (50% of animals), (b) short prepatent period and an inability to resolve the infection (14% of animals) and (c) no patent parasitaemia at any stage of observation (23. 5% of animals). The calorie‐deficienl animals had significantly lower parasitaemia (P<0.05) compared with well fed animals. Protein deficiency resulted in depression of T‐dependent immune responses in uninfected as well as P. berghei ‐infected animals. The outcome of the parasitaemia in protein‐ as well as calorie‐deficient animals seems to be the combined result of deficiencies of certain essential nutrients, proteins and calories in the diet as well as the immune responses of the host.