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CELL‐MEDIATED IMMUNE RESPONSE TO ROSS RIVER VIRUS IN MICE: EVIDENCE FOR A DEFECTIVE EFFECTOR CELL RESPONSE
Author(s) -
Aaskov JG,
Dalglish DA,
Davies CEA,
Tucker M,
Donaldson MD
Publication year - 1983
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1983.50
Subject(s) - virus , spleen , immune system , cytotoxic t cell , biology , effector , immunology , virology , in vitro , biochemistry
Summary Spleen cells recovered from mice during a primary infection with Ross River virus showed a virus‐specific proliferative response when challenged in vitro . The majority of the proliferating cells were T‐lymphocytes. In contrast, there was liltle detectable migration inhibition factor produclion by these spleen cells and little or no virus‐specific cytotoxic activity. Sub‐cutaneous challenge with virus elicited a weak delayed type hypersensitivity reaction.