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THE ENHANCEMENT OF CULTURED SPONTANEOUS CYTOTOXIC T CELLS FROM NORMAL AND ATHYMIC (nu/nu) MICE
Author(s) -
Skinner Margot,
Marbrook John
Publication year - 1983
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1983.43
Subject(s) - cytotoxic t cell , spleen , clone (java method) , cytotoxicity , microbiology and biotechnology , effector , biology , lymphokine activated killer cell , natural killer t cell , immunology , chemistry , interleukin 21 , in vitro , gene , genetics
Summary Subsets of natural killer cells may be characterised by the target cell profile, cell surface markers and the effect of growth factors on the production of effector cells. The subset which appears in primary cultures (spontaneous or natural T killer cells) is enhanced by the supernatants of Con A‐stimulated rat spleen cultures. The enhancement can be attributed to an increased number of clones rather than an expansion of clone size in 5‐day cultures. With semi‐purified IL‐2 preparations, clones of spontaneous cytotoxic cells are also detectable in nu/nu spleen cultures. These results suggest such spontaneous cytotoxicity is a general phenomenon within cytotoxic responses.