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INDUCTION OF T CELL HYPORESPONSIVENESS TO BEBARU IN MICE, AND ABNORMALITIES IN THE IMMUNE RESPONSES OF PROGENY OF HYPORESPONSIVE MALES
Author(s) -
Müllbacher A,
Ashman RB,
Blanden RV
Publication year - 1983
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1983.17
Subject(s) - offspring , immune system , alphavirus , biology , cytotoxic t cell , immunology , alphavirus infection , mouse strain , endocrinology , gene , pregnancy , genetics , in vitro , virus
Summary Non‐specific hyporesponsiveness of cytotoxic T cells to alphaviruses and alloantigens was induced in male mice by multiple, large injections, starting at birth, of gamma‐inactivated alphavirus, stock‐grown in outbred mouse brains. Offspring of matings between 2 out of 17 treated males and normal females also exhibited significant non‐specific hyporesponsiveness (in comparison with normal control mice), without prior exposure to gamma‐inactivated alphavirus stock.