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CELLULAR BASIS FOR DIFFERENCES IN HUMORAL IMMUNE RESPONSES OF SHEEP IMMUNIZED WITH LIVING OR KILLED STAPHYLOCOCCUS AUREUS VACCINES
Author(s) -
Kennedy JW,
Watson DL
Publication year - 1982
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1982.66
Subject(s) - staphylococcus aureus , immune system , antibody , adjuvant , immunization , group a , immunology , antibody response , medicine , biology , bacteria , genetics
Summary An immunohistological study was made of immunoglobulin‐containing cells and antibody‐containing cells in abscesses/granulomas which formed al the injection site, draining popliteal nodes and contralateral popliteal nodes of sheep given either a living Staphylococcus aureus vaccine (Group L), a killed S. aureus vaccine with Frennd's complete adjuvant (FCA) (Group K) or FCA alone (Group C). The injections were made subcutaneously in the hind legs and second injections were gives 4 weeks later in the same site. Very large numbers of IgM‐containing cells were found in granulomas of Groups K and C at 1 week post‐injection (PI) but by 2 weeks PI only small numbers were recorded. Following booster immunization, the numbers of IgM‐containing cells were greater in abscesses from sheep in Group L than from granulomas from sheep in Group K. Levels for Group C remained low after 1 week PI. There was evidence that the very early IgM‐containing cell response in Group K was largely unrelated to specific anti‐staphylococcal antibody synthesis. The IgG 2 ‐containing cell response was significantly greater than the IgG 1 ‐containing cell response in abscesses and nodes in Group L. In contrast, for animals in Groups K and C the IgG 1 ‐containing cell response predominated over the IgG 2 ‐containing cell response in granulomas and draining nodes. There were generally greater numbers of cells containing anti‐staphylococcal antibody in abscesses granulomas and nodes in Group L than in Group K.

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