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ISLET ALLOGRAFTING WITHOUT IMMUNOSUPPRESSION: REVERSAL OF INSULITIS‐ASSOCIATED DIABETES AND A CASE OF SPONTANEOUS JUVENILE ONSET DIABETES IN MICE
Author(s) -
Prowse Stephen J,
Steele Edward J,
Lafferty Kevin J
Publication year - 1982
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1982.64
Subject(s) - insulitis , immunosuppression , islet , diabetes mellitus , juvenile , medicine , immunology , endocrinology , biology , genetics
Summary The development of juvenile onset diabetes may involve an auto immune response causing an insulitis and beta cell destruction. It has been suggested that replacement of the host's beta cells by transplantation may lead to the destruction of the new tissue by the same processes which caused the destruction of the original beta cells. This study does not support this proposal It was possible to reverse insulitis‐induced diabetes and spontaneous murine ‘Juvenile onset’ diabetes by transplantation of cultured islet allografts. The grafts survived and maintained normoglycaemia for periods in excess of 100 days.