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INVESTIGATIONS INTO THE PHARMACOLOGICAL EFFECTS OF SPONGIATRIOL
Author(s) -
Marwood John F
Publication year - 1982
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1982.30
Subject(s) - blood pressure , heart rate , medicine , acetylcholine , in vitro , pharmacology , blockade , prostaglandin , serotonin , stomach , cats , anesthesia , endocrinology , chemistry , receptor , biochemistry
Summary Acute intraperitoneal doses of spongiatriol, a compound extracted from marine sponges, caused blood pressure but not heart rate to fall in conscious hypertensive rats in a dose‐dependent manner up to 50 mg/kg at which dose mean blood pressure fell 24%. Diarrhoea also resulted. Chronic oral doses (50 mg/kg every 3 h) lowered blood pressure by 73 mmHg after 48 h in conscious hypertensive rats and caused severe diarrhoea. Spongiatriol was an atrial stimulant in vitro and this effect could be greatly reduced by prior reserpinization or by β‐adrenoceptor blockade. In anaesthetized cats spongiatriol (50 mg/kg i.p.) caused reductions in blood pressure (19%), heart rate (11%) and cardiac output (12%). Spongiatriol 10 −5 g/ml had no effect on the response to noradrenaline in isolated rat tail arteries, markedly inhibited the response of in vitro guinea‐pig ilea to acetylcholine and had a slight potentiating effect on the response of in vitro rat fundus stomach to serotonin and prostaglandin E 2 .