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DISTRIBUTION OF α1 ‐ANTITRYPSIN (PI) SUBTYPES FROM NEWBORNS
Author(s) -
Mulley John C
Publication year - 1982
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1982.23
Subject(s) - zygosity , locus (genetics) , allele , pi , genetics , biology , allele frequency , population , phenotype , gene , medicine , biochemistry , environmental health
Summary PI phenotypes were determined from 420 cord bloods from Adelaide. Allele frequencies for the subvariants P1*M1, P1*M2 and P1*M3 were 0·73, 0·14 and 0·09, respectively. The combined frequency of other alleles was 0·04. This relatively high level of variation makes PI useful for gene mapping, paternity testing and zygosity testing. For this locus the average probability of detecting non‐paternity in this population is 28%.