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TOXICITY STUDIES OF THE TOXINS ISOLATED FROM ANNUAL RYEGRASS ( LOLIUM RIGIDUM ) INFECTED BY CORYNEBACTERIUM RATHAYI
Author(s) -
Berry PH,
Vogel P
Publication year - 1982
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1982.13
Subject(s) - lolium rigidum , toxicity , toxin , biology , glycolipid , acute toxicity , lolium , zoology , chemistry , microbiology and biotechnology , toxicology , biochemistry , agronomy , poaceae , medicine , weed , herbicide resistance
Summary Estimates of the LD 50 's of 7 glycolipid toxins (corynetoxins) isolated from toxic annual ryegrass varied in the range 0·1–1·3 mg/kg in 2‐week‐old rats. The delay in onset of neurological signs in rats and sheep was independent of dose rate and could be the result of inhibition of protein biosynthesis. In sheep, no influence of the route of administration on the delay in onset of neurological signs was demonstrated. The relationship between the partial structures of the two major corynetoxins and their toxicity is discussed.