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THE EFFECT OF DOPAMINE ON HUMAN GASTRIC SMOOTH MUSCLE
Author(s) -
Thompson BK,
Carle DJ
Publication year - 1982
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1982.12
Subject(s) - phenoxybenzamine , dopamine , endocrinology , haloperidol , medicine , dopamine receptor , stimulation , inhibitory postsynaptic potential , chemistry , propranolol , receptor , isoprenaline , smooth muscle , biology
Summary Dopamine had inhibitory effects on contractions of human gastric smooth muscle strips. Inhibition of spontaneous contractions occurred at high concentrations only, the mean maximum inhibition being 17% at a concentration of 4·7 × 10 −4 M. It was unaffected by haloperidol (10 −5 M) or textrodotoxin (10 −6 M) but was abolished by a combination of phenoxybenzamine (10 −5 M) and propranolol (10 −5 M). Isoprenaline caused a dose‐dependent inhibition of spontaneous contractions with mean maximal inhibition at a concentration of 4·6 × 10 −6 M. These results suggest that there are no specific dopamine receptors in human gastric smooth muscle and that dopamine‐induced inhibitory effects are due to stimulation of adrenergic receptors.