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MODELS FOR THE METABOLIC PRODUCTION OF OXALATE FROM XYLITOL IN HUMANS: A ROLE FOR FRUCTOKINASE AND ALDOLASE
Author(s) -
James Heather M,
Bais Renze,
Edwards John B,
Rofe Allan M,
Conyers Robert AJ
Publication year - 1982
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1982.11
Subject(s) - aldolase a , fructokinase , glycolaldehyde , transketolase , xylitol , chemistry , biochemistry , oxalate , fructose , fructose bisphosphate aldolase , metabolism , transaldolase , enzyme , pentose phosphate pathway , glycolysis , fermentation , organic chemistry , catalysis
Summary It has been proposed previously that oxalate precursors may be formed in the transketolase reaction during the metabolism of xylitol. It is shown in this paper that fructokinase and aldolase, purified from human liver, provide an alternative model in that, in coupled sequence, they produce glycolaldehyde, an oxalate precursor, from D‐xylulose via D‐xylulose I‐phosphate; D‐fructose does not give rise to glycolaldehyde. It is concluded that metabolic pathways based on a combination of the transketolase, fructokinase and aldolase reactions can account for the production of glucose, lactate, tetronates (D‐threonic and D‐erythronic acids) and oxalate (precursors) during the metabolism of xylitol administered parenterally.