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LYMPHOKINE (INTERLEUKIN 2) SECRETION AS A MEASURE OF T CELL RECOGNITION OF PARASITE ANTIGENS
Author(s) -
Prowse SJ
Publication year - 1981
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1981.61
Subject(s) - lymphokine , antigen , secretion , immune system , biology , immunology , parasite hosting , interleukin 2 , lymph node , t cell , endocrinology , world wide web , computer science
Summary The secretion of the lymphokine. Interleukin 2 (IL2), from cells obtained from the lymph nodes of mice infected by the murine nematode. Nematospiroides dubius , is used an indication of T cell recognition of parasite antigens. It is demonstrated that IL2 secretion is T cell‐dependent and occurs only when the lymph node cells are cultivated in the presence of at least 5 μg/ml of a parasite antigen preparation. The presence of adherent peritoneal exudate cells from uninfected mice in the cultures is an essential requirement for lyraphokine release. This system can be used to quantitate T cell recognition of parasite antigens and to study T cell/antigen‐presenting‐cell interactions involved in the immune response to parasite infection.