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THE INHIBITION OF BACTERIAL CELL GROWTH BY KETONE BODIES
Author(s) -
Potezny Nicholas,
Atkinson Elinor R,
Rofe Allan M,
Conyers Robert AJ
Publication year - 1981
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1981.57
Subject(s) - citrobacter freundii , enterobacter aerogenes , ketone , ketone bodies , growth inhibition , bacterial growth , citrobacter , escherichia coli , biochemistry , cell growth , chemistry , klebsiella pneumoniae , enterobacter , biology , bacteria , metabolism , organic chemistry , genetics , gene
Summary The effect of ketone bodies on the growth, in culture, of Escherichia coli was investigated. Both growth and glucose utilisation were inhibited in the presence of 20 mmol/l D‐3‐hydroxybutyrate. Lower concentrations of D‐3‐hydroxybutyrate caused proportionally less inhibition of growth. Acetoacetate also inhibited growth but other glycolytic inhibitors and chemical analogues of D‐3‐hydroxybutyrate either did not inhibit or proved to be too toxic for bacterial growth. Citrate enhanced the ketone body effect. D‐3‐hydroxybutyrate also inhibited the growth of Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii and Salmonella typhimurium . The possible relationship between ketone body inhibition of cell growth and oxygen limitation is discussed.