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CHANGES IN THE CONCENTRATION OF SOMATOMEDIN‐LIKE ACTIVITY IN AMNIOTIC FLUID AND MATERNAL PLASMA FROM RHESUS MONKEYS DURING THE LAST THIRD OF GESTATION
Author(s) -
Falconer J,
Robinson JS
Publication year - 1981
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1981.55
Subject(s) - amniotic fluid , gestation , somatomedin , gestational age , andrology , endocrinology , pregnancy , bioassay , medicine , amniotic sac , chemistry , fetus , biology , hormone , growth hormone , genetics
Summary Somatomedin‐like activity (SLA) was measured in serial samples of amniotic fluid and maternal plasma from Rhesus monkeys ( Macaca mulatta ) using the porcine costal cartilage disc bioassay. Samples of both amniotic fluid and maternal plasma gave dose response curves which were parallel to the human plasma standard. Concentrations of SLA were consistently lower in amniotic fluid (0.43 ± 0.02, mean ± S.E.M., units/ml, n = 33) than in maternal plasma (0.60 ± 0.03 units/ml, n = 31). No significant changes in concentrations of SLA with gestational age were found during the period studied (90‐170 days of pregnancy). The presence of SLA in amniotic fluid is consistent with the possibility that somatomedin plays a role in the control of foetal or placental growth in the primate.