Premium
THE EFFECT OF IRON AND PROTEIN DEFICIENCY ON PLASMA LEVELS AND PARASITE UPTAKE OF [ 14 C] FENBENDAZOLE IN RATS INFECTED WITH NIPPOSTRONGYLUS BRASILIENSIS
Author(s) -
Prichard RK,
Kelly JD,
Bolin TD,
Duncombe VM,
Fagan MR
Publication year - 1981
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1981.49
Subject(s) - fenbendazole , nippostrongylus brasiliensis , anthelmintic , biology , iron deficiency , parasite hosting , blood proteins , pharmacokinetics , pharmacology , immunology , endocrinology , medicine , helminths , ecology , computer science , anemia , world wide web
Summary The Nippostrongylus brasiliensis ‐rat model was used to determine whether iron and protein deficiency, which are commonly associated with parasitic infections, affected the pharmacokinetic behaviour of fenbendazole as measured by plasma concentrations and uptake by worms. Plasma 14 C concentrations after [ 14 C] fenbendazole administration were higher in iron and protein‐deficient rats than in sufficient rats. However, the uptake of 14 C by N. brasiliensis in iron and protein‐deficient rats was significantly less than in worms from diet‐sufficient rats. The reduced anthelmintic uptake by worms in protein and iron‐deficient hosts may account, in part, for reduced anthelmintic efficacy under these circumstances. These findings are relevant to understanding variations in response to chemotherapy in populations of parasitised hosts containing malnourished individuals.