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RESISTANCE TO CUTANEOUS LEISHMANIASIS IN GENETICALLY SUSCEPTIBLE BALB/c MICE
Author(s) -
Mitchell Graham F,
Curtis Joan M,
Handman Emanuela
Publication year - 1981
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1981.48
Subject(s) - cutaneous leishmaniasis , balb/c , antigen , corynebacterium parvum , subcutaneous injection , adjuvant , leishmania major , immunology , intradermal injection , biology , leishmaniasis , virology , leishmania , immune system , parasite hosting , world wide web , computer science , bioinformatics
Summary When injected cutaneously with promastigotes of an isolate of Leish‐mania tropica , BALB/c mice develop progressive cutaneous disease whereas lesions in BALB/c.H‐2 k mice heal after several weeks. Lesions in BALB/c mice injected into deep subcutaneous tissues with promastigotes are less obvious early but much more prominent later than in mice after strict intradermal injection. BALB/c mice injected with Corynebacterium parvum together with a preparation of frozen and thawed infected macrophages are more resistant to cutaneous disease than mice injected with either adjuvant or crude antigen mixture alone. Results of these experiments, and those on other mouse strains reported previously, will aid in the choice of mouse and injection regime to be used in testing the efficacy of isolated L. tropica antigens as vaccines.