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INTERLEUKIN 2 PRODUCTION BY ALLOANTIGEN (H‐2) ACTIVATED T CELLS
Author(s) -
Andrus Linda,
Lafferty Kevin J
Publication year - 1981
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1981.35
Subject(s) - lymphokine , interleukin 2 , cytotoxic t cell , concanavalin a , antigen , stimulation , t cell , chemistry , microbiology and biotechnology , immunology , biology , in vitro , immune system , biochemistry , endocrinology
Summary H‐2 alloantigen‐activated T cells release Interleukin 2 in response to a secondary stimulus by either Concanavalin A or alloantigen. No detectable lymphokine is released in the absence of secondary stimulation and. in the case of alloantigen restimulation, lymphokine release is antigen‐specific. Once formed, however, the lymphokine shows no antigen specificity in its action. Like the precursor of the cytotoxic T cell, the precursor of the Interleukin 2‐producing T cell requires two signals for its activation; alloantigen and a source of costimulator activity. Once activated, T cells will release lymphokine in response to alloantigen alone.