DISTRIBUTION OF THE SIX α 1 ‐ANTITRYPSIN (PI) SUBTYPES FROM A SAMPLE OF BLOOD DONORS | Zendy

Mulley John C | Zendy

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DISTRIBUTION OF THE SIX α 1 ‐ANTITRYPSIN (PI) SUBTYPES FROM A SAMPLE OF BLOOD DONORS

Author(s) -

Mulley John C

Publication year - 1980

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1980.41

Subject(s) - pi , distribution (mathematics) , sample (material) , medicine , chromatography , mathematics , biology , chemistry , mathematical analysis , biochemistry

Summary The PI M phenotype of α 1 ‐antitrypsin was classified into six subtypes determined by three alleles: PI*MI, PI*M2 and PI*M3 . Phenotypes were classified by isoelectric focusing and their distribution agreed closely with Hardy‐Weinberg expectations. The proportion of heterozygotes was 53%. which more than trebles the heterozygosity without subtyping, and is comparable to a recent estimate from U.S. whites.

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