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DISTRIBUTION OF THE SIX α 1 ‐ANTITRYPSIN (PI) SUBTYPES FROM A SAMPLE OF BLOOD DONORS
Author(s) -
Mulley John C
Publication year - 1980
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1980.41
Subject(s) - pi , distribution (mathematics) , sample (material) , medicine , chromatography , mathematics , biology , chemistry , mathematical analysis , biochemistry
Summary The PI M phenotype of α 1 ‐antitrypsin was classified into six subtypes determined by three alleles: PI*MI, PI*M2 and PI*M3 . Phenotypes were classified by isoelectric focusing and their distribution agreed closely with Hardy‐Weinberg expectations. The proportion of heterozygotes was 53%. which more than trebles the heterozygosity without subtyping, and is comparable to a recent estimate from U.S. whites.