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HOMOLOGY BETWEEN ROUNDWORM (ASCARIS) AND HOOKWORM ( N. AMERICANUS ) ANTIGENS DETECTED BY HUMAN IgE ANTIBODIES
Author(s) -
Turner KJ,
Fisher EH,
McWILLIAM AS
Publication year - 1980
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1980.25
Subject(s) - necator americanus , ascaris suum , ascaris , antigen , ascaris lumbricoides , biology , immunoglobulin e , ascariasis , immunology , antibody , helminths
Summary Utilizing the techniques of radioallergosorbent test (RAST), inhibition of RAST and isoelectric focusing on polyacrylamide gels, antigenic cross‐reactivity has been shown between extracts of Ascaris lumbricoides, Ascaris suum and Necator americanus (hookworm). Antigenic homology is extensive between the two Ascaris preparations. The antigens common to hookworm and Ascaris, while representing a minor component of Ascaris body fluid, are nonetheless potent Stimulators of IgE antibody production in subjects infected only with hookworm larvae. These shared antigens appear to have a pI of less than 5.1. The hookworm specific antigens also have a pI of less than 5.1, whereas those specific to Ascaris have pI values in the ranges of 5.0 to 6.0 and 7.0 to 8.6. These latter antigens, i.e. those with pI between 7.0 and 8.6, apparently elicit an immune response only during an active infection with Ascaris.