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INTESTINAL LYMPH AND THE LOCAL ANTIBODY AND IMMUNOGLOBULIN RESPONSE TO INFECTION BY TRICHOSTRONGYLUS COLUBRIFORMIS IN SHEEP
Author(s) -
Adams DB,
Merritt GC,
Cripps AW
Publication year - 1980
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1980.17
Subject(s) - antibody , immunology , lymph , trichostrongylus , immunoglobulin a , antibody response , biology , virology , immunoglobulin g , medicine , helminths , pathology
Summary A local antibody response occurred in the small intestine when immune sheep were challenged with the enteric nematode parasite, Trichostrongylus colubriformis . Incoming infective larvae stimulated the appearance of increased numbers of IgA‐containing lymphocytes in intestinal lymph. There were increases in the populations of IgA‐ and IgG 1 ‐containing plasma cells in the lamina propria. This did not occur in regions of the small intestine distant to the habitat of T. colubriformis . Challenge infection in immune animals increased the titre of anti‐ T. colubriformis haemagglutinating antibody in serum, intestinal lymph, intestinal fluid and extracts of intestinal mucosa. Although immune intestinal lymph contains anti‐ T. colubriformis antibody of IgA isotype, which is presumably produced in intestinal lamina propria, it failed to transfer passive immunity against the parasite. This result, however, does not exclude the possibility that IgA‐antibody responses are important in protective immunity against T. colubriformis .