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LYMPHOCYTE SENSITIZATION IN SHEEP INOCULATED WITH EXTRACTS OF SPONTANEOUSLY OCCURRING MALIGNANT LYMPHOMAS
Author(s) -
Johnstone AC,
Moriarty KM,
Manktelow BW
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.9
Subject(s) - antigen , lymphoma , lymphocytosis , sensitization , lymphocyte , immunology , in utero , macrophage , pathology , biology , medicine , fetus , in vitro , pregnancy , biochemistry , genetics
Summary A macrophage migration inhibition lest showed that the blood lymphocytes of 15 of 27 sheep inoculated in utero or al birth with disrupted cells from ovine malignant lymphomas responded in culture to antigens derived from three other lymphomas. A close association was seen between animals whose lymphocytes were antigen‐sensitive and those which developed lymphocytosis. This association and the specificity of reaction between the various tumour antigens employed in the tests is interpreted as further evidence toward a viral aetiology in ovine malignant lymphoma.