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INHIBITION OF THE GROWTH OF LEWIS LUNG CARCINOMA IN SYNGENEIC MICE BY SALMONELLA ANTIGENS
Author(s) -
Ashman LK,
Kotlarski I
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.67
Subject(s) - lewis lung carcinoma , salmonella , antigen , salmonella enteritidis , carcinoma , lung , microbiology and biotechnology , biology , immunity , bacteria , cancer research , immune system , immunology , medicine , cancer , pathology , genetics , metastasis
Summary Administration of a protein antigen preparation from Salmonella enteritidis 11RX at the site of challenge with Lewis lung carcinoma inhibited tumour development in mice previously immunised with live bacteria, but not control mice. The kinetics of tumour growth indicated that the inhibition of tumour development was due to a reduction of the initial tumour inoculum rather than the development of specific anti‐tumour immunity.