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THE EFFECT OF OESTROGEN ON SELECTIVE TRANSFER OF IgG 1 INTO MAMMARY SECRETION OF EWES
Author(s) -
Darton PJ,
McDowell GH
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.65
Subject(s) - secretion , mammary gland , endocrinology , medicine , biology , chemistry , cancer , breast cancer
Summary Two separate experiment were conducted to examine the effects of exogenous oestrogen on selective transfer of IgG 1 into mammary secretion of ewes. In one experiment, non‐pregnant ewes were induced to lactate artificially by first developing mammary glands with injections of progesterone plus low doses of oestrogen then triggering milk secretion with either glucocorticoid or high doses of oestrogen. In the other experiment, lactating ewes were injected with oestrogen each day for 6 days. The results of the experiments suggest that oestrogen affects selective transfer of IgG 1 into mammary secretion of the ewe. Moreover, the results show that, in the absence of high levels of oestrogen in blood, the magnitude of the selective transfer of IgG 1 into mammary secretion is related inversely to the synthetic activity of the glandular epithelium.