Premium
THE EFFECT OF PHENYLEPHRINE ON EXCRETION OF FLUID AND ELECTROLYTES BY THE PAROTID AND MANDIBULAR GLANDS OF THE RAT
Author(s) -
Young JA,
Cook DI,
Jones G,
McGirr J,
Thompson C
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.57
Subject(s) - phenylephrine , parotid gland , endocrinology , excretion , medicine , chemistry , anatomy , dentistry , blood pressure
Summary The effect has been investigated of the α‐adrenergic agonist, phenylephrine, on excretion of water and electrolytes (Na, K, and HCO 3 ) by the parotid and mandibular glands of the rat. In the mandibular glands the agonist was as effective as acetylcholine (or parasympathetic nerve stimulation) in stimulating secretion, and the electrolyte excretory patterns seen in the two modes of stimulation were similar. In the parotid gland, phenylephrine was only one‐fifth as potent as acetylcholine (or parasympathetic nerve stimulation) in evoking a secretory response but, when due allowance for flow rate differences is made, the electrolyte excretion patterns were similar. In both glands the secretory response to phenylephrine was totally different, in magnitude and in electrolyte excretion pattern, to that evoked by the β‐adrenergic agonist, isoprenaline. It is concluded, as has already been established for secretion of exportable protein, that α‐adrenergic agonists have very similar effects to muscarinic agonists both on endpiece and on duct cells and that these actions are completely different from those evoked by activation of β‐adrenergic receptors.