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DEVELOPMENT IN VITRO OF CYTOTOXIC LYMPHOCYTES AGAINST MURINE CYTOMEGALOVIRUS
Author(s) -
Ho Monto,
Ashman Robert B
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.42
Subject(s) - cytotoxic t cell , in vitro , spleen , cytomegalovirus , virology , biology , antigen , immunology , virus , herpesviridae , genetics , viral disease
Summary Lymphocytes cytotoxic for mouse embryo fibroblasts (MEF) infected with murine cytomegalovirus (MCMV) were produced by in vitro culture of “memory” spleen cells with UV‐irradiated, MCMV‐infected, MEF. Cytotoxic lymphocytes were developed from spleen cells of mice 10 to 240 days after infection with MCMV, The cytotoxic cells carried the theta and Ly 2 antigens, and were H‐2 restricted in the recognition of infected target cells.