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THE SUPPRESSIVE EFFECT OF CIRCULATING SPECIFIC ANTIBODY ON THE RESPONSE TO ORAL IMMUNISATION WITH VIBRIO CHOLERAE
Author(s) -
Horsfall DJ,
Brown MA,
Rowley D
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.30
Subject(s) - vibrio cholerae , immunology , antibody , immune system , antigen , cholera , antibody response , immunization , medicine , microbiology and biotechnology , biology , bacteria , genetics
Summary Specific IgG antibody given intravenously 3–4 hours prior to oral immunisation with Vibrio cholerae led to a specific depression of both the systemic and local immune response. One vibriocidal unit of IgG antibody, which itself would give undetectable levels of circulating specific antibody, was significantly immunosuppresive. The suppression is considered to be due to central repression of antigen‐reactive lymphocyte, rather than to antigen exclusion at the gut mucosal surface. The repression appeared less pronounced in some immunoglobulin classes than in others.