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THE KINETIC BEHAVIOUR OF RADIOLABELLED IgG 1 DERIVED FROM DIFFERENT SOURCES IN ADULT SHEEP AND NEONATAL LAMBS
Author(s) -
Cripps AW,
Steel JW,
Lascelles AK
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.15
Subject(s) - kinetic energy , zoology , chemistry , biology , physics , classical mechanics
Summary The turnover rate and pool volume of radiolabelled autologous IgG 1 was similar to homologous IgG 1 in adult sheep. In neonatal lambs there was no significant difference for either of these parameters between homologous serum IgG 1 and maternal colostrum IgG 1 . However, the pool volume for IgG 1 expanded by approx. 30% over the experimental period in the lambs. When the turnover rates were corrected for this increase they were found to be similar to those observed for IgG 1 in adult animals.