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RADIOIMMUNOASSAY OF SECRETIN IN SERUM
Author(s) -
Ho P,
Hansky J
Publication year - 1979
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1979.10
Subject(s) - secretin , radioimmunoassay , medicine , endocrinology , basal (medicine) , chemistry , microgram , pancreas , biochemistry , in vitro , insulin
Summary A radioimmnunoassay for the measurement of immunoreactive secretin has been developed. The assay is specific and sensitive so that 2·8 fmol/ml can be measured. Basal secretin levels inn man are generally undetectable and a protein‐rich meal does not elicit a secretin reponse. However, the intraduodenal instillation of HCl leads to a prompt rise in circulating immunoreactive secretin and exogenous secretin administered intravenously is easily and accurately measured.