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THE SOURCE OF IgM AND IgG IN THE DOG INTESTINE
Author(s) -
Heddle RJ,
Rowley D
Publication year - 1978
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1978.78
Subject(s) - antibody , immunoglobulin m , immunoglobulin g , immunology , small intestine , immunoglobulin a , chemistry , biology , medicine
Summary The source of IgM and IgG 2a, b in the dog intestine was investigated, using labelled dog immunoglobulins and chronic Thiry‐Vella loops of dog small intestine. Clearances of IgM and IgG 2a, b from serum into intestinal secretions were similar, reflecting transfer of a greater mass of IgG 2a, b than of IgM. Only 20% of the intestinal IgM derived from, serum, irrespective of the marker used. About one third of the total intestinal IgG, of all sub‐classes and accrued from all sources, was serum‐derived IgG 2a, b . This indicates that serum is a major contributor to dog intestinal IgG 2a, b .