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ALPHA TOCOPHEROL AND BLOOD PRESSURE IN PN/n MICE
Author(s) -
Wigley RD,
Vlieg M
Publication year - 1978
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1978.71
Subject(s) - arteritis , alpha tocopherol , blood pressure , intraperitoneal injection , endocrinology , medicine , tocopherol , chemistry , biology , vitamin e , biochemistry , antioxidant
Summary The tail cuff blood pressure of PN/n mice, previously studied for arteritis and glomerulitis, was found to be raised before histological changes appeared. The pressures of mice bred for two generations on a diet containing a low level of alpha tocopherol (E) fell to that of control CBA mice. Replacement of E in the diet, or by intraperitoneal injection, led to a rise of pressure. The pressures reached a mean of 150 mm/Hg after breeding the mice for a further three generations on a more complete diet with additional E. An inhibitory effect of E on prostaglandin production was postulated. E had no effect on the pressures of CBA/MAC mice.