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NEMATOSPIROIDES DUBIUS : SUSCEPTIBILITY TO INFECTION AND THE DEVELOPMENT OF RESISTANCE IN HYPOTHYMIC (NUDE) BALB/c MICE
Author(s) -
Prowse SJ,
Mitchell GF,
Ey PL,
Jenkin CR
Publication year - 1978
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1978.62
Subject(s) - resistance (ecology) , biology , balb/c , virology , immunology , ecology , immune system
Summary BALB/c‐nu/nu mice and their intact nu/+ littermates are equally susceptible to infection with third‐stage larvae of Nematospiroides dubius . Unlike their heterozygous littermates. however, the nu/nu mice are unable to form granulomata in the intestinal wall and become only partially resistant to rechallenge. Following two or more infections, nu/nu mice maintain a high burden of adult intestinal worms, whereas worms are lost from immune nu/+ mice. Studies in T cell‐injected nu/nu mice suggest that a full complement of T cells is needed to develop maximum resistance against the infective third‐stage larvae and to expel adult worms. Measurement of serum immunoglobulin levels indicate that infected nu/+ mice have very high levels of IgG 1 whereas the levels of IgG 2a are reduced. In infected T cell‐injected nu/nu mice, IgG 1 levels increase with the number of T cells injected, whereas IgG 2a levels are variable but always higher than in infected nu/+ mice.