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PROTECTION OF MICE AGAINST PLASMODIUM AND BABESIA INFECTIONS: ATTEMPTS TO RAISE HOST‐PROTECTIVE SERA
Author(s) -
Mitchell GF,
Handman E,
Howard RJ
Publication year - 1978
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1978.61
Subject(s) - plasmodium berghei , plasmodium yoelii , biology , virology , plasmodium (life cycle) , babesia , malaria , host (biology) , parasitemia , immunology , parasite hosting , plasmodium falciparum , genetics , world wide web , computer science
Summary In an attempt to generate large numbers of mice resistant to Plasmodium berghei and Babesia rodhaini to be used as donors of antibody‐secreting cells for hybridoma production, various methods of inducing resistance to repeated challenge with infected blood cells have been explored. Although, results of independent experiments varied markedly, prior injection of CBA/H mice with BCG. and prior infection of BALB/c mice with Plasmodium yoelii, were found to be manipulations capable of inducing resistance to P. berghei . A single dose of serum, harvested from resistant mice challenged several times with P. berghei, could transfer resistance against P. berghei to a proportion of naive CBA/H recipients. Although resistance to multiple B. rodhaini challenge could be induced in mice, in no situation was a host protective effect of a single high dose of serum demonstrated in naive recipients.