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THE EFFECTS OF AGENTS MODIFYING SYMPATHETIC NERVE FUNCTION ON THE RESPONSE OF THE ISOLATED RAT TAIL ARTERY TO ETILEFRINE AND TYRAMINE
Author(s) -
Frost BR,
Frewin DB,
Gerke DC,
Downey JA
Publication year - 1978
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1978.56
Subject(s) - tyramine , reserpine , guanethidine , catecholamine , chemistry , monoamine oxidase , monoamine oxidase inhibitor , medicine , endocrinology , pharmacology , biochemistry , stimulation , enzyme
Summary The effects of etilefrine on the ventral caudal artery of the rat have been examined in the presence of agents modifying sympathetic nerve function. Catecholamine levels were also measured in adjacent segments of artery to those studied pharmacologically and an attempt made to relate vascular response to etilefrine (and tyramine) with catecholamine content. Both guanethidine and reserpine produced significant attenuation of the vascular effects of etilefrine and tyramine. Pre‐treatment with a monoamine oxidase inhibitor caused an increase in tissue catecholamine levels but, paradoxically, depressed the vascular response to etilefrine. The significance of some of the findings in terms of an indirect component to etilefrine's action are discussed.