DISTRIBUTION OF SURFACE IgM AND IgD ON SINGLE CELLS FROM LYMPHOCYTE SUBPOPULATIONS | Zendy

Layton Judith E | Zendy; Howard Maureen C | Zendy

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DISTRIBUTION OF SURFACE IgM AND IgD ON SINGLE CELLS FROM LYMPHOCYTE SUBPOPULATIONS

Author(s) -

Layton Judith E,

Howard Maureen C

Publication year - 1978

Publication title -

australian journal of experimental biology and medical science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.999

H-Index - 104

eISSN - 1440-1711

pISSN - 0004-945X

DOI - 10.1038/icb.1978.49

Subject(s) - immunoglobulin d , surface immunoglobulin , spleen , antiserum , lymphocyte , antibody , microbiology and biotechnology , immunology , chemistry , biology , b cell

Summary The surface immunoglobulin heavy chains on individual spleen cells fractionated by velocity sedimentation were studied using fluorescent antisera. In adult mice, cells bearing both μ and δ chains were found in all fractions. While there was an increase in the proportion of cells bearing μ only in the medium to large cell fractions, the majority of cells bearing μ only were small lymphocytes. Results obtained using 3‐week‐old mice were basically similar, but showed both a marked decrease in small μ+ δ+ cells and a marked increase in small μ + δ ‐ cells when compared with adult animals.

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