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DISTRIBUTION OF SURFACE IgM AND IgD ON SINGLE CELLS FROM LYMPHOCYTE SUBPOPULATIONS
Author(s) -
Layton Judith E,
Howard Maureen C
Publication year - 1978
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1978.49
Subject(s) - immunoglobulin d , surface immunoglobulin , spleen , antiserum , lymphocyte , antibody , microbiology and biotechnology , immunology , chemistry , biology , b cell
Summary The surface immunoglobulin heavy chains on individual spleen cells fractionated by velocity sedimentation were studied using fluorescent antisera. In adult mice, cells bearing both μ and δ chains were found in all fractions. While there was an increase in the proportion of cells bearing μ only in the medium to large cell fractions, the majority of cells bearing μ only were small lymphocytes. Results obtained using 3‐week‐old mice were basically similar, but showed both a marked decrease in small μ+ δ+ cells and a marked increase in small μ + δ ‐ cells when compared with adult animals.