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PROTEIN AND DNA LEVELS IN THE SUBMANDIBULAR SALIVARY GLANDS OF ISOPROTERENOL STIMULATED MICE
Author(s) -
Feiglin B,
Reade PC
Publication year - 1978
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1978.1
Subject(s) - muscle hypertrophy , dna synthesis , dna , medicine , endocrinology , chemistry , submandibular gland , biochemistry , biology , microbiology and biotechnology
Summary The DNA and soluble and sedimental protein levels were studied in isoproterenol stimulated mouse .submandibular salivary glands over a period of 200 h. Hypertrophy, the predominant cellular phenomenon following chronic isoproterenol treatment, was assoeiated with a marked elevation of 14 C‐Icucine incorporation into the buffer soluble protein fraction and a less pronounced isotope incorporation into the sedimental sub‐cellular fraction as well as continued DNA synthesis. These findings are contrary to the accepted definitions of hypertrophy which preclude continued DNA synthesis. A suggestion is made, therefore, that in the system used the polyploidy associated with the hypertrophy involves DNA synthesis.