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STUDIES ON IMMUNE RESPONSES TO LARVAL CESTODES IN MICE:
Author(s) -
Mitchell Graham F,
Handman Emanuela
Publication year - 1977
Publication title -
australian journal of experimental biology and medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0004-945X
DOI - 10.1038/icb.1977.59
Subject(s) - larva , immune system , biology , cestoda , zoology , helminths , cestode infections , ecology , immunology
Summary After intraperitoneal (i.p.) injection of sheep erythrocytes (SRBC) or dinitrophenylated Ficoll (DNP‐Ficoll), mice infected with the larval cestode, Mesocestodes corti , contain at least 20x fewer antibody‐secreting cells (PFC) in their spleens (or spleens plus lymph nodes) than uninfected mice. By contrast, intravenous injection of antigen leads to normal PFC responses. Results of studios on the fate of labelled syngeneic erythrocytes and foreign proteins surest that i.p. injected materials are retained in the inflamed peritoneal cavity. Sequestration of antigen, and its subsequent local destruction, presumably accounts for the markedly suppressed systemic immune responses induced by i.p. injected antigens in M. corti ‐infected mice.